Remove the real transparency change handler, it won't work while the window is realised, and unrealising it effectively destroys it, so this looks like the only setting that will actually hard-require a restart

terminatorlib/prefs_profile.py

@@ -274,10 +274,6 @@ class ProfileEditor:
             self.term.maximize()
           else:
             self.term.unmaximize()
-        elif changer == "enable_real_transparency":
-          #self.term.enable_rgba(values[changer])
-          # FIXME: This breaks if the window is realised
-          pass
         elif changer == "borderless":
           self.term.window.set_decorated (not values[changer])
         elif changer == "handle_size":